Adderall IR vs Adderall XR. What’s the difference?

Adderall IR vs Adderall XR. What’s the difference?

Adderall is a well-known medication used to treat ADHD that has been on the market since 1996.  Years after its initial approval, Shire Pharmaceuticals developed an “extended-release” format of the drug called “Adderall XR.”  This format of the drug was launched in 2001 as a means to provide extended relief from attentional-deficits spanning up to 12 hours.

Those taking the original version of Adderall (immediate-release) often would end up having to take multiple pills throughout the day due to the fact that the effect only lasted 4 to 6 hours.  This complicated treatment, especially for children that would need school nurses to take extra time to administer treatment.  Fortunately Adderall XR was a solution that could be used to combat popping an extra Adderall IR tablet.

The Adderall XR capsule contains beads with the same active ingredient as Adderall IR; 75% dextroamphetamine and 25% levoamphetamine.  The primary difference between the two is that Adderall XR elicits nearly double the duration of effect.  Some people claim to tolerate one format than the other, which is likely due to physiological differences in absorption of the beads within the XR compared to the tablet of the IR.

Adderall IR vs Adderall XR comparison chart.

Below is a chart created to help you analyze the general similarities and differences between Adderall IR and XR.

                                  Adderall IR                                       Adderall XR

Generic name

Mixed Amphetamine Salts

Amphetamine Salt Combo XR

Duration of effect

4 to 6 hours. (Shorter-acting)

~12 hours. (Longer-acting)

Format

Tablet (100% immediate-release)

Capsule (50% immediate-release, 50% delayed-release)

Dosages

5 mg, 7.5 mg, 10 mg, 12.5 mg, 15 mg, 20 mg, 30 mg

5 mg, 10 mg, 15 mg, 20 mg, 25 mg, 30 mg

Release date

1996

2001

Adderall

Adderall IR vs Adderall XR. What’s the difference?

Due to the fact that both Adderall IR and Adderall XR contain the same active ingredient of 75% dextroamphetamine and 25% levoamphetamine, there theoretically shouldn’t be any significant difference in terms of efficacy.  There also shouldn’t be any significant differences in terms of side effects.  Whether you respond better to one format of the drug over the other is highly individual – another person may have a completely different response.

Adderall IR is manufactured in tablet format, whereas Adderall XR is manufactured in the form of capsules.  The capsules of the Adderall XR contain little beads, 50% of which are immediate-release (just like the “IR”) and 50% of which are delayed-release.  The total duration of effect provided by Adderall XR is estimated to be approximately 12 hours, whereas that of Adderall IR is between 4 and 6 hours.

Abuse Potential-

Both the immediate-release (IR) and extended-release (XR) versions of Adderall are classified as “Schedule II” controlled-substances.  This means that they have a high potential for abuse, are habit forming, and may result in dependence.  Psychological dependence is most common among Adderall users that come to rely on the drug as a crutch to help them perform better at school/work, function in social settings, or maintain a positive mood.

Some may argue that since the “IR” version is in tablet format, it is subject to greater abuse.  This may be true due to the fact that snorting Adderall is easier for those seeking a “high” when in tablet form compared to capsule form.  Tablets can be easily crushed, whereas those attempting to insufflate the capsules will have a more difficult time emptying and crushing the beads.

Without crushing the beads within the capsules, they will not elicit any sort of any effect.  From the perspective of insufflation, the tablets likely have a greater propensity for abuse.  That said, abuse of either drug can result in high dopamine levels, which may trigger “stimulant psychosis.”  For this reason, both Adderall IR and XR are carefully regulated by medical professionals.

 

Crashes-

Most users of Adderall have experienced what is commonly referred to as an Adderall crash.  This is a temporary “crash” in terms of both physical and mental energy that occurs when Adderall’s effect wears off.  Most people aren’t bothered by these crashes due to the fact that they only take Adderall to help with work and/or school, when they’re finally home, the crash isn’t important.

That said, crashes aren’t thought to be more common with the IR compared to the XR or vice-versa.  Those taking high doses of the IR may find that they experience a noticeable crash after 4 hours, compared to a noticeable crash after 12 hours as would occur with the XR.  Some may find that being medicated for a longer period of time throughout the day with the XR increases the severity and duration of the crash.

There will be significant individual differences in regards to whether you experience a crash after your Adderall wears off.  Generally the greater the contrast between your “medicated state” and your “non-medicated state,” the more noticeable the crash.  Some individuals may resort to taking a combination of the XR, followed by an IR dose so that their only “crash” is a good night’s sleep.

Dosage-

The available dosages for Adderall IR include: 5 mg, 7.5 mg, 10 mg, 12.5 mg, 15 mg, 20 mg, and 30 mg.  The dosage options for Adderall XR include: 5 mg, 10 mg, 15 mg, 20 mg, 25 mg, and 30 mg.  As you can tell, there are smaller increments between doses of the IR version.  Should someone find that 5 mg is too light of a dose, whereas 10 mg is too heavy of a dose, the option of 7.5 mg may prove to be optimal.

That said, Adderall XR still is manufactured in six different dosing options, just one shy of the IR version.  It provides a 25 mg dose that is not available for Adderall IR and still provides steady increments of 5 mg between dosing formats.  Overall, there really isn’t a significant difference between Adderall IR and XR in terms of dosing options.  Some may prefer the smaller incremental increases of the IR dosing, while others may like the 25 mg option of the XR.

The doses associated with Adderall IR compared to XR can be difficult for some to understand.  Taking 10 mg of Adderall XR would be equivalent to taking 5 mg of Adderall IR twice.  In other words, a 10 mg Adderall XR would be like taking 2 separate, optimally-timed doses of 5 mg Adderall IR.

Duration of Effect-

There are noticeable differences in duration of effect between Adderall IR and XR.  Those taking the IR should find that the effect lasts approximately 4 to 6 hours.  For some people the effect may seem shorter, while for others it may seem to last the full 6 hours.  In general, it is somewhere in the middle – around 5 hours depending on how your body absorbs the tablet.

The Adderall XR version was engineered specifically to last up to 12 hours.  This means you can take just one of the XRs and you should experience symptomatic reduction for the entire day.  Despite differences in duration of effect, a person could easily take 2 Adderall IRs and be covered for up to 12 hours as well.  For those that favor convenience and simplicity, taking only one pill of the XR for long-term relief may be preferred.

Effect-

Anecdotal reports across the internet will claim that Adderall XR is better than Adderall IR – and vice-versa.  This may be somewhat of a placebo effect, but could also be due to absorption differences.  Some people may have an easier time absorbing the Adderall IR in tablet format compared to the beads within the capsules of Adderall XR.

Assuming your body absorbs one pill better than the other or more smoothly, it could result in a slight difference in terms of efficacy.  Delivery of the drug and how it’s processed matters, but just because the IR works better for you, does not mean that it will work better for someone else.  That said, since both Adderall IR and XR contain the same ratio of mixed salts, the effect should be nearly identical.

Formats-

Adderall IR is formatted in an immediate-release tablets.  This means that as soon as you take the drug, you’ll get the full effect of the drug within 30 to 60 minutes; many people feel it sooner.  Adderall XR is formatted in capsule form containing  pellets.  Within these capsules, 50% of the pellets are immediate-release, and 50% are delayed-release.

This means that when you take Adderall XR, you’ll get the same initial kick within 30 to 60 minutes as you would with the IR version.  However, you’ll notice that the drug delivers a “second wind” of effect after the immediate-release pellets are fully processed.  This “second wind” is from the other delayed-release pellets that haven’t broken down.

By comparison, the immediate-release pellets are comprised of a bead in the center of a drug layer, followed by an overcoating.  The delayed-release pellets are comprised of a bead in the center of a drug layer, with an overcoating covered in a release-delaying polymer, covered with a second overcoating.  This means that as the first immediate-release pellets are “wearing off” the delayed-release pellets are just kicking in.

The combination of immediate and delayed release pellets results in a bimodal distribution of effect that could be achieved by simply taking 2 properly-timed immediate-release tablets.  For the sake of convenience, many people like the Adderall XR format.  However, if you don’t always need a “second wind” after your first 4 to 6 hours, Adderall IR may be preferred.

Medical Uses-

Both Adderall IR and XR are approved for the treatment of ADHD and narcolepsy.  Those with these conditions may prefer to use one format of Adderall over the other, or may use a combination of both.  Some individuals with ADHD may have a supply of both Adderall IR and XR to use based on how much cognitively-demanding work they’ll be doing.

Those with long school or work days may opt to take the XR version for 12 hours worth of relief.  Individuals that only need to focus for 4 to 6 hours may rather take the IR version and feel less drugged for the remainder of the day.  Individuals with narcolepsy may find that Adderall XR doesn’t provide quite as long of relief as they need, and may take an Adderall IR for additional relief when the XR wears off.

Popularity-

Among those looking to abuse Adderall, the immediate-release format may be slightly more popular.  This is due to the fact that it’s far easier to crush up a tablet for insufflation, than it is to crush up the tiny pellets within the extended-release version.  That said, there isn’t specific data in regards to whether Adderall IR or XR is the more popular format among general users.

Those who wish to attain longer-lasting relief will gravitate towards the XR version, whereas those who need shorter-term relief tend to like the IR version.  Some speculate that Adderall XR may be slightly more popular than the IR due to the fact that it is newer and longer-acting.  From a general perspective, Adderall (both IR and XR) is regarded as one of the most popular psychostimulants of all time.

Side Effects-

Due to the fact that the ingredient composition is the exact same in Adderall IR and XR, the side effects are likely to be the same.  Common side effects associated with both versions include: appetite loss, diarrhea, dizziness, dry mouth, fever, headaches, insomnia, nausea, nervousness, stomach pain, vomiting, and weight loss.  Slight variations in side effects may be due to differences in absorption of the tablet-formatted IR or the capsule-formatted XR.

Withdrawal-

There may be some differences in severity and duration of withdrawal related to whether you took Adderall IR or XR.  Those taking the immediate-release (IR) version may not use the drug as frequently or on an intermittent basis.  This intermittent or infrequent usage associated with the immediate-release version may result in less severe Adderall withdrawal symptoms.

Those taking the extended-release version (XR) may be medicated more throughout the day, and therefore may have an increasingly difficult time stopping the drug.  Furthermore, should you want to “taper” or titrate your dosing downwards, there are bigger jumps in dosing increments of 5 mg with the XR version compared to 2.5 mg increments with the IR version.  Unfortunately pellets cannot be “counted” due to the fact that you won’t know which are the immediate versus the delayed release.

Adderall IR can be cut with a pill cutter, making it easier to titrate the dosing downwards.  Therefore, the immediate-release version may be advantageous in that it is more likely to be used on an intermittent or infrequent basis, the pills can be cut, and the dosing options provide smaller increments for tapering.

Similarities-

Below is a recap of the similarities between Adderall IR and XR.

  • Mechanism of action: The mechanism of action for Adderall IR and XR is the exact same as they contain the same active ingredients.  They both act as dopamine reuptake inhibitors, plus inhibit reuptake of norepinephrine, and trigger the presynaptic release of these neurotransmitters.
  • Medical uses: Both formats of Adderall are used to treat ADHD and narcolepsy.  Some patients may prefer one format over the other, but in many cases a combination of both may be utilized.
  • Ingredients: The IR and XR version of Adderall are both comprised of 75% dextroamphetamine and 25% levoamphetamine.
  • Side effects: There should be no significant differences in side effects derived from Adderall IR compared to Adderall XR.
  • Withdrawal: The symptoms associated with discontinuing each drug are likely similar if administered as the same dose.  However, those taking the IR may experience less severe withdrawals due to intermittent or less-frequent daily usage that may not last a full 12 hours like the XR.  Being medicated for a full 12-hours daily may produce a more substantial withdrawal.  That said, if you were taking two Adderall IRs, you’ll likely have the same degree of withdrawal as someone taking one Adderall XR.

Difference between Adderall IR and Adderall XR

Listed below is a recap of the differences between immediate-release and extended-release Adderall.

  • Approval date: Adderall IR was approved in 1996, whereas Adderall XR didn’t hit the market until 2001.
  • Dosages: There are a total of 7 dosing options for Adderall IR and the lower doses increase in 2.5 mg increments.  There are a total of 6 dosing options for Adderall XR, all of which increase in 5 mg increments.
  • Duration of effect: The duration of effect for the IR version is 4 to 6 hours, whereas the XR version is thought to last up to 12 hours.
  • Format: The format of Adderall IR is that of a tablet containing mixed amphetamine salts.  The format of Adderall IR is that of a capsule containing “pellets” (50% immediate-release and 50% delayed-release).

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